HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 5-Oxo-pyrrolidine-3-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 5-Oxopyrrolidine-3-carboxylic acid | HCID 16785136 | — |
| Product | 5-Oxo-pyrrolidine-3-carboxylic acid methylamide | HCID 55220663 | — |
Reaction Steps
In an analogous manner to that described in Example 24f), by condensing (R)-1-(4-benzyloxy)-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid with methylamine using HBTU as the condensation agent there is obtained (R)-1-(4-benzyloxy)-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methylamide as a white solid. MS: m/e=325 (M+H)+; [α]589=−27.55° (c=0.958, CH2Cl2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07037935B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-e421d638fa094c4d8fc46b4ca6306a1e |
| Source note | uspto-grants-2006_05 |