Ammonium formate → Methyl 4'-(2-aminoethyl)-2-methyl-1,1'-biphenyl-4-carboxylate

Participants

Reaction Steps

A mixture of methyl 4′-[2-[[(benzyloxy)carbonyl]-amino]ethyl]-2-methyl-1,1′-biphenyl-4-carboxylate (650 mg), ammonium formate (500 mg) and palladium on carbon powder (400 mg) in methanol (10 ml) and water (1.0 ml) was refluxed for 2 hours. The reaction mixture was filtrated and poured into water and extracted with chloroform. The organic layer was washed with brine, dried over magnesium sulfate and evaporated to give methyl 4′-(2-aminoethyl)-2-methyl-1,1′-biphenyl-4-carboxylate (380 mg).

Provenance & Evidence