反应详情

Under nitrogen, 4-methoxy-1-naphthoic acid (4.33 g) in dichloromethane (45 ml) was added boron tribromide (1M in dichloromethane, 63 ml) dropwise at 0° C., and the mixture was stirred at the same temperature for 2 hours. The resulting mixture was poured into ice-cold water and the precipitate was collected by filtration. The filter cake was added to the mixture of water and ethyl acetate, and then adjusted to pH 9 with 1N sodium hydroxide. After separation, the organic layer was dried over anhydrous magnesium sulfate and evaporated in vacuo to afford 4-hydroxy-1-naphthoic acid (2.19 g) as a colorless powder.

1. additionThe resulting mixture was poured into ice-cold water
2. filtrationthe precipitate was collected by filtration
3. additionThe filter cake was added to the mixture of water and ethyl acetate
4. customAfter separation
5. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
6. customevaporated in vacuo