HCID 69549477, compound → (2S, 4R)-5-oxo-4-(3-phenyl-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Participants

Reaction Steps

A solution of the compound obtained from Step A (6.0 g) and Pd/C (10%, 620 mg) in methanol (150 mL) was hydrogenated at 40 psi in a par-shaker for 3.0 h. Pd/C was removed by filtration through a pad of celite. Removal of solvent under reduced pressure gave practically pure product as a viscous oil. 1HNMR (300 MHz, CDCl3) δ 7.29–7.14 (m, 5H), 4.53 (d, J=9.5 Hz, 1H), 4.22 (q, J=7.0 Hz, 2H), 2.60 (m, 3H), 2.20 (m, 1 H), 1.98 (m, 2H), 1.64 (m, 2H), 1.50 (s, 9H), 1.28 (t, J=7.0 Hz, 3H).

Provenance & Evidence