Citric Acid → HCID 69799959, compound

Participants

Reaction Steps

To the ester from Step E (78 mg, 0.18 mmol) dissolved in methanol (1.0 mL) was added LiOH (1.0 M, 0.36 mL). The mixture was stirred at rt for 1.5 h. It was acidified with 5% citric acid, and extracted with EtOAc. The organic layer was washed with brine and dried over MgSO4. Evaporation of solvent and lyopholization gave 70 mg white solid used directly in the next Step.

Provenance & Evidence