Potassium bis(trimethylsilyl)amide → HCID 69652769, compound

Participants

Reaction Steps

Dissolve (3-{[3-(3,5-dichloro-pyridin-4-yl)-5-methyl-isoxazole-4-carbonyl]amino}-cyclohexylmethyl)-carbamic acid benzyl ester (0.60 g, 0.0012 mol) in N,N-dimethylformamide (5 mL) at ambient temperature under a nitrogen atmosphere. Add a solution of potassium bis(trimethylsilyl)amide (0.5 M in toluene, 2.32 mL, 0.0012 mol) and stir for 20 min. at ambient temperature. Quench the dark mixture with water and follow by the adding solid sodium chloride. Extract with ethyl acetate and dry over sodium sulfate. Concentrate and elute over silica gel with methanol/dichloromethane to give 0.33 g (58%) of the desired product. MS(ES): (M+1)+ 481.0 m/z.

Provenance & Evidence