Hydrochloric Acid → HCID 22170145, compound

Participants

Reaction Steps

Combine 3-(3,5-dichloro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (0.755 g, 0.0025 mol) with aqueous sodium hydroxide (2N, 6.0 mL, 0.012 mol), ethanol (2 mL), and tetrahydrofuran (2 mL) and stir overnight at ambient temperature. Add water and adjusted to approx. pH 3.0 with aqueous hydrochloric acid. Extract with ethyl acetate and dry over sodium sulfate and concentrate in vacuo. Drying nets the desired isoxazole acid as a tan solid(0.65 g, 95%). MS (ES): (M+1)+ 273.0,275.0 m/z.

Provenance & Evidence