4-(4-amino-2-butyl 1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamine → HCID 178441565, compound

HRID 1823403Notes

Reaction equation

HRID 1823403 reaction equation
[OH:1][C:2]1[C:7]([CH3:8])=[CH:6][N:5]([CH2:9][C:10]([OH:12])=O)[C:4](=[O:13])[N:3]=1.[NH2:14][C:15]1[C:24]2[N:25]=[C:26]([CH2:33][CH2:34][CH2:35][CH3:36])[N:27]([CH2:28][CH2:29][CH2:30][CH2:31][NH2:32])[C:23]=2[C:22]2[N:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:16]=1>>[NH2:14][C:15]1[C:24]2[N:25]=[C:26]([CH2:33][CH2:34][CH2:35][CH3:36])[N:27]([CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:10](=[O:12])[CH2:9][N:5]3[CH:6]=[C:7]([CH3:8])[C:2]([OH:1])=[N:3][C:4]3=[O:13])[C:23]=2[C:22]2[N:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:16]=1

Participants

3

Reactant 2

HCID 129926164-(4-amino-2-butyl 1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamineHCID 178430593HCID 178430593, compound

Product 1

HCID 178441565HCID 178441565, compoundYield 19.6%

Procedure

Using the general method of Example 105 2-(4-hydroxy-5-methyl-2-oxo-1,2-dihydro-1-pyrimidinyl)acetic acid (0.12 g, 64 mmol) was reacted with 4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamine (0.2 g, 0.64 mmol) to provide 0.06 g of N1-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-2-(4-hydroxy-5-methyl-2-oxo-1,2-dihydro-1-pyrimidinyl)acetamide as a solid, m.p. 242–244° C.

Sources & evidence

ORD record
ord-2145dfbb9eed4056b1234c893fd5bb2f
Source dataset
uspto-grants-2006_05
Patent number
US07038051B2

Reaction notes

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