反应详情

2-Chloro-5-(trifluoromethyl)pyridine (5.0 g) was heated with ethylenediamine (20 ml) at 120° C. overnight. The excess ethylenediamine was removed by rotary evaporation and the residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide. The aqueous layer was extracted 5 times further with dichloromethane. The combined organic layers were washed with a saturated aqueous sodium chloride solution, dried, then concentrated in vacuo to give (2-aminoethyl)[5-(trifluoromethyl)(2-pyridyl)]amine as an orange oil.

1. customThe excess ethylenediamine was removed by rotary evaporation
2. customthe residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide
3. extractionThe aqueous layer was extracted 5 times further with dichloromethane
4. washThe combined organic layers were washed with a saturated aqueous sodium chloride solution
5. customdried
6. concentrationconcentrated in vacuo