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HRID 1823429作成日：2026年10月25日
Dimethylformamide dimethyl acetal → 4-[(2E)-3-(dimethylamino)-2-imidazolylprop-2-enoyl]benzenecarbonitrile
https://huagongshe.com/reaction/1823429
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | 4-(2-Imidazolylacetyl)benzenecarbonitrile | HCID 22142999 | — |
| 生成物 | 4-[(2E)-3-(dimethylamino)-2-imidazolylprop-2-enoyl]benzenecarbonitrile | HCID 69310575 | — |
反応手順
A mixture of 4-(2-imidazolylacetyl)benzenecarbonitrile (0.30 M) and N,N-dimethylformamide dimethyl acetal (DMFDMA) (80 ml) was stirred for 12 h at 75° C. The DMFDMA was then removed under reduced pressure and dried under high vacuum for several hours giving an orange-yellow solid 4-[(2E)-3-(dimethylamino)-2-imidazolylprop-2-enoyl]benzenecarbonitrile in quantitative yield. The enaminone product was typically used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07037918B2 |
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| 出典データセット | uspto-grants-2006_05 |
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| ORD ID | ord-a02329e084b342ecbb94fd3597a3671c |
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| 出典メモ | uspto-grants-2006_05 |
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