Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → Ethyl 6-({2-[(5-nitro(2-pyridyl))amino]ethyl}amino)-2-phenylpyridine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| 반응물 | Ethyl benzoylacetate | HCID 7170 | — |
| 반응물 | 2-Chloropyridine | HCID 7977 | — |
| 반응물 | {2-[(6-Amino-5-nitro(2-pyridyl))amino]ethyl}[6-(2,4-dichlorophenyl)-5-imidazolyl(2-pyridyl)]amine | HCID 22142808 | — |
| 반응물 | Ethyl 6-chloro-2-phenylpyridine-3-carboxylate | HCID 22142863 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Diisopropylethylamine | HCID 81531 | — |
| 생성물 | Ethyl 6-({2-[(5-nitro(2-pyridyl))amino]ethyl}amino)-2-phenylpyridine-3-carboxylate | HCID 22142365 | — |
반응 단계
ethyl 6-({2-[(5-nitro(2-pyridyl))amino]ethyl}amino)-2-phenylpyridine-3-carboxylate was prepared from ethyl 3-oxo-3-phenylpropanoate as the starting material and DDQ in the oxidation step. The final product is achieved directly from the chloropyridine by reacting ethyl 6-chloro-2-phenylpyridine-3-carboxylate with 2-(2-aminoethylamine)-5-nitropyridine in CH3CN and Hünig's base at 80° C. for 18 hours. The procedures are analogous to the general method for {2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[6-(2,4-dichlorophenyl)-5-imidazolyl(2-pyridyl)]amine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07037918B2 |
| 출처 데이터셋 | uspto-grants-2006_05 |
| ORD ID | ord-7b4bd2646c3d42aa84fffa2018e8c18b |
| 출처 메모 | uspto-grants-2006_05 |