5,5-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione → (1S,2S,5R,6S)-2-Amino-2-(3'-chlorobenzyloxycarbonyl)-bicyclo [3.1.0]hexane-6-carboxylic acid

Participants

Reaction Steps

(1S,2S,5R,6S)-2-Allyloxycarbonylamino-2-(3′-chloro-benzyloxycarbonyl)-bicyclo[3.1.0]hexane-6-carboxylic acid (708 mg, 1.8 mmol) was reacted with dimethylbarbituric acid (421 mg, 2.7 mmol) and tetrakis triphenylphosphine palladium (0) (42 mg; 0.02 mmol) under general procedure 4. The title compound was obtained as a white solid (385 mg, 62% yield).

Provenance & Evidence