Sodium triacetoxyborohydride → HCID 9805331, compound

Participants

Reaction Steps

To a mixture of 2-(1-amino-2-methyl-propyl)-3-benzyl-3-H-pyrido[2,3-d]pyrimidin-4-one (983 mg, 3.188 mmol), Na(OAc)3BH (1.352 g, 6.376 mmol) and dichloromethane (25 mL) was added a solution of t-butyl-N-(3-oxopropyl)-carbamate (714 mg, 3.51 mmol) in dichloromethane (25 mL) dropwise. The reaction mixture was stirred at room temperature for 30 minutes, diluted with 100 mL of dichlorometane, washed with saturated sodium bicarbonate, H2O, brine and dried (Na2SO4). After concentration, the desired product of Formula 108, N-{3-[1-(3-benzyl-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl)-2-methyl-proplyamino]-propyl}-carbamic acid tert butyl ester, was obtained as a white solid (1.45 g, 98%).

Provenance & Evidence