Sodium triacetoxyborohydride → HCID 69314010, compound

Participants

Reaction Steps

To a solution of dichloromethane (100 mL), 2-(1-amino-2-methyl-propyl)-3-benzyl-3H-pyrido[4,3-d]pyrimidin-4-one (1.92 mmol) and Na(OAc)3BH (0.814 g, 3.84 mmol), was added t-butyl-N-(3-oxopropyl)-carbamate (0.400 g, 2.30 mmol) at room temperature. The mixture was stirred at room temperature for 3 hours, after which it was diluted with dichloromethane (100 mL), washed with saturated sodium bicarbonate, water and brine, and dried over sodium sulfate. After concentration under reduced pressure, the desired product {3-[1-(3-benzyl-4-oxo-3,4-dihydro-pyrido[4,3-d]pyrimidin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester (0.850 g, 95%) was obtained in sufficiently pure form to be carried forward for use in the next step. MS (Cl) M/E: 466.2.

Provenance & Evidence