Water → HCID 22147930, compound

HRID 1823853Notes

Reaction equation

HRID 1823853 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH:9][NH:10][C:11](=[O:22])C1C=CC(C(F)(F)F)=CC=1)=O.ClC1C=CSC=1C(NN)=O.[F:33][C:34]([F:45])([F:44])[C:35]1[CH:43]=[CH:42][C:38](C(Cl)=O)=[CH:37][CH:36]=1.O>N1C=CC=CC=1>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[O:22][CH2:11][N:10]([C:38]2[CH:37]=[CH:36][C:35]([C:34]([F:33])([F:44])[F:45])=[CH:43][CH:42]=2)[N:9]=1

Participants

6

Reactant 4

HCID 962WaterHCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 22147888HCID 22147888, compoundHCID 23570764HCID 23570764, compound

Product 1

HCID 22147930HCID 22147930, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-(3-Chloro-thiophene-2-carbonyl)-N′-(4-trifluoromethylbenzoyl)-hydrazine: A solution of 3-chloro-2-thiophenecarboxylic acid hydrazide (70.4 mg, 0.4 mmol), 4-trifluoromethylbenzoyl chloride (83.6 mg, 0.4 mmol) in pyridine (5 mL) was refluxed for 4 h and then cooled. The solution was diluted by water and the precipitate was collected by filtration, and then dried to yield 129 mg (93%) of the title compound.

Workup

  1. temperaturecooled
  2. filtrationthe precipitate was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-e06e845580514c7cbb8ecb23d910020f
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Reaction notes

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