3-Chlorothiophene-2-carbonyl chloride → 5-[5-(3-Chloro-2-thienyl)-1,2,4-oxadiazol-3-yl]-2-methoxypyridine

Participants

Reaction Steps

The title compound was prepared as in Example 16 from 3-chloro-thiophene-2-carbonyl chloride (0.150 g, 0.828 mmol) and 6-methoxy-pyridine-3-amidoxime (0.138 g, 0.828 mmol) as a white solid (166 mg, 63%). 1H NMR (DMSO-d6): 8.84 (d, J=2.4 Hz, 1H), 8.28 (m, 1H), 8.20 (d, J=6.0 Hz, 1H), 7.42 (d, J=5.1 Hz, 1H), 7.04 (d, J=9.3 Hz, 1H).

Provenance & Evidence