3-Chlorothiophene-2-carbonyl chloride → 3-(4-Aminopyrimidin-5-yl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole

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Reaction Steps

The title compound was prepared from 4-amino-pyrimidine-5-amidoxime (50 mg, 0.33 mmol) and 3-chloro-thiophene-2-carbonyl chloride (59 mg, 0.33 mmol), similar to Example 16, and yielded 25 mg (27%) of yellow solid. 1H NMR (CDCl3): 9.18 (s, 1H), 8.69 (s, 1H), 7.66 (d, J=5.22 Hz, 1H), 7.16 (d, J=5.22 Hz, 1H), 5.85 (s, 1H), 3.51 (s, 1H).

Provenance & Evidence