4-(Trifluoromethyl)benzoyl chloride → 3-(3-Bromo-thiophen-2-yl)-5-(4-trifluoromethyl-phenyl)-[1,2,4]-oxadiazole

Participants

Reaction Steps

The title compound was prepared from 4-trifluoromethyl-benzoyl chloride (66 μL, 0.44 mmol) and 3-bromo-thiophene-2-amidoxime (98 mg, 0.44 mmol) similar to Example 16, and yielded 130 mg (78%) of white solid. 1H NMR (CDCl3): 8.34 (d, J=8.24 Hz, 2H), 7.83 (d, J=8.51 Hz, 2H), 7.52 (d, J=5.22 Hz, 1H), 7.19 (d, J=5.21 Hz, 1H).

Provenance & Evidence