3-Chlorothiophene-2-carbonyl chloride → HCID 9967366, compound

HRID 1823865Notes

Reaction equation

HRID 1823865 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[N:8]=[CH:7][C:6]([C:9](=[N:11][OH:12])[NH2:10])=[CH:5][CH:4]=1.[Cl:15][C:16]1[CH:20]=[CH:19][S:18][C:17]=1[C:21](Cl)=O>>[Cl:15][C:16]1[CH:20]=[CH:19][S:18][C:17]=1[C:21]1[O:12][N:11]=[C:9]([C:6]2[CH:7]=[N:8][C:3]([C:2]([F:13])([F:1])[F:14])=[CH:4][CH:5]=2)[N:10]=1

Participants

3

Reactant 2

HCID 27358243-Chlorothiophene-2-carbonyl chlorideHCID 27777596-trifluoromethyl-pyridine-3-amidoxime

Product 1

HCID 9967366HCID 9967366, compound

Procedure

The title compound was prepared from 6-trifluoromethyl-pyridine-3-amidoxime (418 mg, 2.04 mmol) and 3-chloro-thiophene-2-carbonyl chloride (369 mg, 2.04 mmol) similar to Example 16, and yielded 538 mg (80%) of white solid. 1H NMR (CDCl3): 9.49 (m, 1H), 8.63 (m, 1H), 7.85 (dd, J=8.24, 0.82 Hz, 1H), 7.66 (d, J=5.49 Hz, 1H), 7.17 (d, J=5.22 Hz, 1H).

Sources & evidence

ORD record
ord-6c4aac7983d0489a938d08854915a39f
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Reaction notes

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