3-Chlorothiophene-2-carbonyl chloride → HCID 22147903, compound

HRID 1823872Notes

Reaction equation

HRID 1823872 reaction equation
[N+:1]([C:4]1[S:8][C:7]([C:9](=[N:11][OH:12])[NH2:10])=[N:6][CH:5]=1)([O-:3])=[O:2].[Cl:13][C:14]1[CH:18]=[CH:17][S:16][C:15]=1[C:19](Cl)=O>>[Cl:13][C:14]1[CH:18]=[CH:17][S:16][C:15]=1[C:19]1[O:12][N:11]=[C:9]([C:7]2[S:8][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][N:6]=2)[N:10]=1

Participants

3

Reactant 2

HCID 27358243-Chlorothiophene-2-carbonyl chlorideHCID 3783389HCID 3783389, compound

Product 1

HCID 22147903HCID 22147903, compound

Procedure

The title compound was prepared from 5-nitro-thiazole-2-amidoxime (17.2 mg, 0.0914 mmol) and 3-chloro-thiophene-2-carbonyl chloride (16.4 mg, 0.0905 mmol) similar to Example 16, and yielded 6.7 mg (23%) of yellow solid. 1H NMR (CDCl3): 8.74 (s, 11H), 7.70 (d, J=5.22 Hz, 1H), 7.18 (d, J=5.22 Hz, 1H).

Sources & evidence

ORD record
ord-966d38c9fc3741b794063377464330c7
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Reaction notes

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