6-Chloronicotinoyl Chloride → HCID 22147922, compound

HRID 1823884Notes

Reaction equation

HRID 1823884 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][CH2:9][C:10]([C:12]2[S:13][CH:14]=[CH:15][C:16]=2[Cl:17])=[O:11])=O)=[CH:4][N:3]=1.Cl.ClC1C=CSC=1C(=O)CN.ClC1C=CC(C(Cl)=O)=CN=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]2[O:11][C:10]([C:12]3[S:13][CH:14]=[CH:15][C:16]=3[Cl:17])=[CH:9][N:8]=2)=[CH:18][CH:19]=1

Participants

4

Reactant 3

HCID 27821656-Chloronicotinoyl ChlorideHCID 22147914HCID 22147914, compoundHCID 692498842-(3-Chloro-thiophen-2-yl)-2-oxo-1-ethylamine hydrochloride

Product 1

HCID 22147922HCID 22147922, compound

Procedure

6-Chloro-N-[2-(3-chloro-thiphen-2-yl)-2-oxo-ethyl]-nicotinamide: The title compound was prepared from 2-(3-chloro-thiophen-2-yl)-2-oxo-1-ethylamine hydrochloride and 6-chloronicotinoyl chloride by a procedure similar to Example 98a as a white solid (0.044 g, 30%). 1H NMR (CD3OD): 8.74 (d, J=8.74 Hz, 1H), 8.13 (d, J=6.3 Hz, 1H), 7.79 (d, J=5.4 Hz, 1H), 7.48 (d, J=9.0 Hz, 1H), 7.07 (d, J=5.4 Hz, 1H), 4.75 (s, 2H).

Sources & evidence

ORD record
ord-f89d5c49a66b45e99c97cb10783e7804
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Reaction notes

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