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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18239Generated: October 26, 2026

1,3-dimethyl-1H-indole-2-carbaldehyde → 2,3-dihydro-8-(methylaminomethyl)-1H-3a-azacyclopenta[a]indene

https://huagongshe.com/reaction/18239

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
Reactant2,3-dihydro-1H-3a-azacyclopenta[a]indene-8-carboxaldehydeHCID 5323989—
Product2,3-dihydro-8-(methylaminomethyl)-1H-3a-azacyclopenta[a]indeneHCID 2213904854%

Reaction Steps

According to the procedure of Preparation 13 (c), except substituting 2,3-dihydro-1H-3a-azacyclopenta[a]indene-8-carboxaldehyde (0.17 g, 0.92 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.1 g, 54%) was prepared as a yellow oil: MS (ES) m/e 201 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-a2da06eee0134b8e87d91a037684dd14
Source noteuspto-grants-2010_06