Lithium Hydroxide → HCID 6480679, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-methyl (Z)-2-(benzoylamino)-3-[4-(2-methylphenoxy)phenyl]prop-2-enoate (104 mg, 0.29 mmol), prepared as described above, in dioxane (5 mL) is added 1 N LiOH (5 mL). The reaction mixture is stirred at 25° C. for 3 hours. The dioxane is then removed under reduced pressure and the remaining reaction mixture poured into a separatory funnel. The aqueous layer is washed with diethyl ether and then acidified (pH=4) by treatment with 10% HCl causing a white precipitate to develop. A portion of ethyl acetate (50 mL) is added and the organic layer is separated, dried over sodium sulfate and concentrated to afford 75 mg of (Z)-2-(benzoylamino)-3-[5-(2-methylphenyl)-2-furyl]prop-2-enoic acid which does not require a further purification.

Provenance & Evidence