Salicyluric Acid → HCID 69599200, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-(2-bromophenoxy)benzaldehyde (0.35 g, 1.26 mmol), 2-hydroxy hippuric acid (0.22 g, 1.14 mmol) and sodium acetate (0.12 g, 1.48 mmol) in acetic anhydride (1 mL) is heated to 60° C. on an orbital shaker for one hour and is then cooled to 0° C. The reaction mixture is then concentrated under reduced pressure at 45° C. to afford a crude yellow solid. This solid is washed with ice water (150 mL) and heptane (100 mL) and then dried under vacuum at 40° C. to provide 0.475 g of 2-{(4Z)-4-[4-(2-bromophenoxy)benzylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl acetate.

Provenance & Evidence