Salicyluric Acid → HCID 69598887, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-(2-chlorophenoxy)benzaldehyde-(0.193 g, 0.83 mmol, 2-hydroxy hippuric acid (0.147 g, 0.75 mmol) and sodium acetate (0.08 g, 0.975 mmol) in acetic anhydride (0.5 mL) is heated to 60° C. on an orbital shaker for one hour and is cooled to room temperature. The reaction mixture is concentrated under reduced pressure at 45° C. to provide an orange solid. The solid is washed with ice water (150 mL) and heptane (100 mL) and dried under vacuum at 40° C. to provide 0.32 g 2-{(4Z)-4-[4-(2-chlorophenoxy)benzylidene]-5-oxo-4,5-dihydro-1,3-oxazol-2-yl}phenyl acetate.

Provenance & Evidence