Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate → HCID 22147989, compound

HRID 1823970Notes

Reaction equation

HRID 1823970 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]=[C:11](B2OC(C)(C)C(C)(C)O2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:24]1[S:28][C:27]([C:29]2[CH:30]=[CH:31][C:32]3[CH2:39][CH:38]4[C:40]5([CH2:44][N:43]([CH2:45][C:46]([F:49])([F:48])[F:47])[S:42](=[O:51])(=[O:50])[NH:41]5)[CH:35]([CH2:36][CH2:37]4)[CH2:34][C:33]=3[CH:52]=2)=[N:26][CH:25]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]=[C:11]([C:24]2[S:28][C:27]([C:29]3[CH:30]=[CH:31][C:32]4[CH2:39][CH:38]5[C:40]6([CH2:44][N:43]([CH2:45][C:46]([F:47])([F:48])[F:49])[S:42](=[O:51])(=[O:50])[NH:41]6)[CH:35]([CH2:36][CH2:37]5)[CH2:34][C:33]=4[CH:52]=3)=[N:26][CH:25]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 4642098Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylateHCID 22147984HCID 22147984, compound

Product 1

HCID 22147989HCID 22147989, compound

Procedure

Prepared from the boronate from Step 2 and the bromide from Example 36, Step 2 by the method described for Example 36, Step 3. Contains ˜10% unsubstituted thiazole.

Sources & evidence

ORD record
ord-f374a642768942de9543ffb528e8c447
Source dataset
uspto-grants-2006_05
Patent number
US07041689B2

Reaction notes

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