4-Fluorophenylboronic acid → 4-Methyl-5-(4-fluorophenyl)thiazole

HRID 1823973Notes

Reaction equation

HRID 1823973 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1Br.[F:8][C:9]1[CH:14]=[CH:13][C:12](B(O)O)=[CH:11][CH:10]=1>>[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[C:12]1[CH:13]=[CH:14][C:9]([F:8])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 150209975-Bromo-4-methyl-1,3-thiazole

Product 1

HCID 221479694-Methyl-5-(4-fluorophenyl)thiazole

Procedure

Prepared from the bromothiazole from Step 1 and 4-fluorobenzeneboronic acid by the method described for Example 36 Step 3.

Sources & evidence

ORD record
ord-3a5f11b66e50447f8953a50605d18e54
Source dataset
uspto-grants-2006_05
Patent number
US07041689B2

Reaction notes

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