HCID 22147999, compound → HCID 23571081, compound

HRID 1823974Notes

Reaction equation

HRID 1823974 reaction equation
Br[C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[C:5]([CH3:7])[N:6]=1.CC1(C)C(C)(C)OB([C:23]2[CH:24]=[CH:25][C:26]3[CH2:33][C@H:32]4[C@:34]5([CH2:38][N:37]([CH2:39][C:40]([F:43])([F:42])[F:41])[S:36](=[O:45])(=[O:44])[NH:35]5)[C@H:29]([CH2:30][CH2:31]4)[CH2:28][C:27]=3[CH:46]=2)O1>>[CH3:7][C:5]1[N:6]=[C:2]([C:23]2[CH:24]=[CH:25][C:26]3[CH2:33][C@H:32]4[C@:34]5([CH2:38][N:37]([CH2:39][C:40]([F:43])([F:42])[F:41])[S:36](=[O:44])(=[O:45])[NH:35]5)[C@H:29]([CH2:30][CH2:31]4)[CH2:28][C:27]=3[CH:46]=2)[S:3][C:4]=1[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 22147999HCID 22147999, compoundHCID 23571079[6s,9r,11r]2',3',4',5,5',6,7,8,9,10-Decahydro-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-5'-(2,2,2-trifluoroethyl)spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazole]1',1'-dioxide

Product 1

HCID 23571081HCID 23571081, compound

Procedure

Prepared from the bromothiazole from Step 3 and the homochiral boronate from Example 24 Step 1 by the method described for Example 36 Step 3. MS (ES+) 552 ([MH]+).

Sources & evidence

ORD record
ord-162364fa828e4a46b98deacef0959414
Source dataset
uspto-grants-2006_05
Patent number
US07041689B2

Reaction notes

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