3-Fluorophenylboronic acid → CID 23571066

HRID 1823993Notes

Reaction equation

HRID 1823993 reaction equation
Br[C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[F:7][C:8]1[CH:9]=[C:10](B(O)O)[CH:11]=[CH:12][CH:13]=1.CC1(C)C(C)(C)OB([C:25]2[CH:26]=[CH:27][C:28]3[CH2:35][C@H:34]4[C@:36]5([CH2:40][N:39]([CH2:41][C:42]([F:45])([F:44])[F:43])[S:38](=[O:47])(=[O:46])[NH:37]5)[C@H:31]([CH2:32][CH2:33]4)[CH2:30][C:29]=3[CH:48]=2)O1>>[F:7][C:8]1[CH:9]=[C:10]([N:5]2[CH:6]=[C:2]([C:25]3[CH:26]=[CH:27][C:28]4[CH2:35][C@H:34]5[C@:36]6([CH2:40][N:39]([CH2:41][C:42]([F:45])([F:44])[F:43])[S:38](=[O:46])(=[O:47])[NH:37]6)[C@H:31]([CH2:32][CH2:33]5)[CH2:30][C:29]=4[CH:48]=3)[N:3]=[CH:4]2)[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 27339863-Fluorophenylboronic acidHCID 23571079[6s,9r,11r]2',3',4',5,5',6,7,8,9,10-Decahydro-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-5'-(2,2,2-trifluoroethyl)spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazole]1',1'-dioxideHCID 178418934HCID 178418934, compound

Product 1

HCID 23571066CID 23571066

Procedure

Prepared from 4-bromo-1H-imidazole, 3-fluorophenylboronic acid and homochiral boronate from Example 24 Step 1 following the procedures in Example 76 Steps 1 and 2.

Sources & evidence

ORD record
ord-5089cf195e814dd6b1de684b8b6aaa46
Source dataset
uspto-grants-2006_05
Patent number
US07041689B2

Reaction notes

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