4-Bromo-1-(1-methylethyl)-1H-imidazole → HCID 23571073, compound

HRID 1823996Notes

Reaction equation

HRID 1823996 reaction equation
Br[C:2]1[N:3]=[CH:4][N:5]([CH:7]([CH3:9])[CH3:8])[CH:6]=1.CC1(C)C(C)(C)OB([C:18]2[CH:19]=[CH:20][C:21]3[CH2:28][C@H:27]4[C@:29]5([CH2:33][N:32]([CH2:34][C:35]([F:38])([F:37])[F:36])[S:31](=[O:40])(=[O:39])[NH:30]5)[C@H:24]([CH2:25][CH2:26]4)[CH2:23][C:22]=3[CH:41]=2)O1>>[CH:7]([N:5]1[CH:6]=[C:2]([C:18]2[CH:19]=[CH:20][C:21]3[CH2:28][C@H:27]4[C@:29]5([CH2:33][N:32]([CH2:34][C:35]([F:38])([F:37])[F:36])[S:31](=[O:39])(=[O:40])[NH:30]5)[C@H:24]([CH2:25][CH2:26]4)[CH2:23][C:22]=3[CH:41]=2)[N:3]=[CH:4]1)([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 221479964-Bromo-1-(1-methylethyl)-1H-imidazoleHCID 23571079[6s,9r,11r]2',3',4',5,5',6,7,8,9,10-Decahydro-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-5'-(2,2,2-trifluoroethyl)spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazole]1',1'-dioxide

Product 1

HCID 23571073HCID 23571073, compound

Procedure

Prepared from 4-bromo-1-isopropyl-1H-imidazole (Step 1) and homochiral boronate from Example 24 Step 1 by the procedure described for Example 76 Step 2.

Sources & evidence

ORD record
ord-a7e4cb84393e42a2a709d66b0b5f133f
Source dataset
uspto-grants-2006_05
Patent number
US07041689B2

Reaction notes

Loading…