2-Cyclopenten-1-one → HCID 22139459, compound

HRID 1824005Notes

Reaction equation

HRID 1824005 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2)#[N:2].[C:12]1(=[O:17])[CH2:16][CH2:15][CH:14]=[CH:13]1>>[O:17]=[C:12]1[CH2:16][CH2:15][CH:14]([C:6]2[C:5]3[C:9](=[CH:10][CH:11]=[C:3]([C:1]#[N:2])[CH:4]=3)[NH:8][CH:7]=2)[CH2:13]1

Participants

3

Reactant 2

HCID 135882-Cyclopenten-1-oneHCID 27513Indole-5-carbonitrile

Product 1

HCID 22139459HCID 22139459, compoundYield 82%

Procedure

This compound was prepared in the same manner as for Intermediate 2, using 5-cyanoindole (4.26 g, 30 mmol) and 2-cyclopenten-1-one (2.95 g, 36 mmol) to give 5.5 g (82%) of the desired product: mp 136–138° C.; MS (ESI) m/z 224 [M]+.

Sources & evidence

ORD record
ord-3d477825ce234168ad9d38d163a1b956
Source dataset
uspto-grants-2006_05
Patent number
US07041697B2

Reaction notes

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