HCID 14174697, compound → N-[amino-(4-tert-butylanilino)methylidene]-2-phenylacetamide;hydrochloride

HRID 1824015Notes

Reaction equation

HRID 1824015 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C:11]#[N:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:13].[C:14]([C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1)([CH3:17])([CH3:16])[CH3:15]>>[ClH:13].[C:1]1([CH2:7][C:8]([NH:10][C:11]([NH:22][C:21]2[CH:23]=[CH:24][C:18]([C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:19][CH:20]=2)=[NH:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 14174697HCID 14174697, compoundHCID 221493414-tert-Butylaniline--hydrogen chloride (1/1)

Product 1

HCID 178441023N-[amino-(4-tert-butylanilino)methylidene]-2-phenylacetamide;hydrochlorideYield 69%

Procedure

Synthesis of this compound was achieved by the method set forth in Example 1, Part II above with the use of phenylacetylcyanamide in place of 4-methylbenzoylcyanamide and using 4-t-butylaniline hydrochloride instead of 4-isopropylaniline hydrochloride respectively. Yield 69%; m.p. 182–186° C.; Purity 86% (HPLC); 1H-NMR (CD3OD) δ 1.38 (s, 9H, CH3), 3.84 (s, 2H, CH2), 7.3 (d, 2H, ArH), 7.3–7.45 (m, 5H, ArH), 7.6 (d, 2H, ArH).

Workup

  1. customSynthesis of this compound

Sources & evidence

ORD record
ord-9a3e20269d7e4f82b2191fb44f244b75
Source dataset
uspto-grants-2006_05
Patent number
US07041702B1

Reaction notes

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