反应详情

Following the procedure for the preparation of (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol but substituting 2-chloro-4-dimethylaminophenylboronic acid and making non-critical variations provided the title compound as a pale yellow amorphous solid. IR (diffuse reflectance) 2969, 2932, 1607, 1567, 1550, 1486, 1443, 1391, 1353, 1225, 1207, 1177, 1043, 961, 740 cm−1; OAMS ESI+ 437.2; MS (EI) m/z 436 (M+); HRMS (FAB) calcd for C25H29CLN4O+H1 437.2108, found 437.2089. [α]25D=−7 (c 0.70, methylene chloride); Anal. Calcd for C25H29ClN4O: C, 68.72; H, 6.69; N, 12.82. Found: C, 68.48; H, 6.84; N, 12.66.