3-(2,4-Dichlorophenyl)-2,5-diethylpyrazine 1-oxide → 2-Bromo-5-(2,4-dichlorophenyl)-3,6-diethylpyrazine

HRID 1824066Notes

Reaction equation

HRID 1824066 reaction equation
[Br:1]C1C(C)=NC(C2C=CC(Cl)=CC=2Cl)=C(C)N=1.[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[C:26]1[C:27]([CH2:35][CH3:36])=[N+:28]([O-])[CH:29]=[C:30]([CH2:32][CH3:33])[N:31]=1>>[Br:1][C:29]1[C:30]([CH2:32][CH3:33])=[N:31][C:26]([C:20]2[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:19]=2[Cl:18])=[C:27]([CH2:35][CH3:36])[N:28]=1

Participants

3

Reactant 2

HCID 221472153-(2,4-Dichlorophenyl)-2,5-diethylpyrazine 1-oxideHCID 221474252-Bromo-5-(2,4-dichlorophenyl)-3,6-dimethylpyrazine

Product 1

HCID 221474372-Bromo-5-(2,4-dichlorophenyl)-3,6-diethylpyrazine

Procedure

Following the procedure of 2-bromo-5-(2,4-dichlorophenyl)-3,6-dimethylpyrazine but substituting 3-(2,4-dichlorophenyl)-2,5-diethylpyrazine 1-oxide and making non-critical variations provided the title compound as an oil: 1H NMR (CDCl3) δ 1.19 7.5, 1.33, 2.63, 3.02, 7.28, 7.39, 7.54; MS (ESI+) for C14H13Br1Cl2N2 m/z 361.1 (M+H)+.

Sources & evidence

ORD record
ord-c3651997bf524177893cd4008ee74a70
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

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