7-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one → 7-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine

HRID 1824087Notes

Reaction equation

HRID 1824087 reaction equation
O1C2CCCC([NH2:10])C=2C=C1.[CH3:11][O:12][C:13]1[CH:22]=[C:21]2[C:16]([CH2:17][CH2:18][CH2:19][C:20]2=O)=[CH:15][CH:14]=1>>[CH3:11][O:12][C:13]1[CH:22]=[C:21]2[C:16]([CH2:17][CH2:18][CH2:19][CH:20]2[NH2:10])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 812767-Methoxy-1,2,3,4-tetrahydronaphthalen-1-oneHCID 185251714,5,6,7-Tetrahydro-1-benzofuran-4-amine

Product 1

HCID 139145927-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine

Procedure

Following the procedure for the preparation of 4,5,6,7-tetrahydro-1-benzofuran-4-amine but substituting 7-methoxy-3,4-dihydronaphthalen-1(2H)-one and making non-critical variations provided the title compound as a oil: 1H NMR (400 MHz, CDCl3) δ 6.99, 6.75, 3.95, 3.82, 2.74, 2.05, 1.96, 1.71, 1.67, 1.56; 13C NMR (100 MHz, CDCl3) δ 158.28, 142.62, 130.30, 129.19, 113.44, 112.88, 55.73, 50.12, 34.17, 29.12, 20.26.

Sources & evidence

ORD record
ord-a8cf183f23114e99a581f0861536b1a6
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

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