3,6-diethyl-N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine → 5-bromo-3,6-diethyl-N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

HRID 1824089Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1824089
[Br:1][C:2]1[N:3]=[C:4]([CH2:21][CH3:22])[C:5]([NH:10][C@@H]2C3C(=CC=CC=3)C[C@@H]2O)=[N:6][C:7]=1[CH2:8][CH3:9].C(C1C(N[CH:34]2[C:43]3[C:38](=[CH:39][CH:40]=[C:41]([O:44][CH3:45])[CH:42]=3)[CH2:37][CH2:36][CH2:35]2)=NC(CC)=CN=1)C>>[Br:1][C:2]1[N:3]=[C:4]([CH2:21][CH3:22])[C:5]([NH:10][CH:34]2[C:43]3[C:38](=[CH:39][CH:40]=[C:41]([O:44][CH3:45])[CH:42]=3)[CH2:37][CH2:36][CH2:35]2)=[N:6][C:7]=1[CH2:8][CH3:9]

Komponenten

3

Edukt 2

HCID 221474653,6-diethyl-N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amineHCID 58583245(1R,2S)-1-[(5-bromo-3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

Produkt 1

HCID 221474025-bromo-3,6-diethyl-N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

Versuchsvorschrift

Following the procedure for the preparation of (1R,2S)-1-[(5-bromo-3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 3,6-diethyl-N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine and making non-critical variations provided the title compound as a oil: 1H NMR (400 MHz, CDCl3) δ 7.08, 6.88, 6.81, 5.36, 4.52, 3.76, 2.79, 2.56, 2.08, 1.91, 1.31; (FAB) calcd for C19H24BrN3O+H 390.0, found 390.0.

Quellen und Nachweise

ORD-Eintrag
ord-19400d2b9292432785c1877a7b218cc9
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07041672B2

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