6-Methoxy-1,2,3,4-tetrahydro-1-naphthalenylamine → 3,6-diethyl-N-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

HRID 1824097노트

반응식

HRID 1824097 반응식
[CH2:1]([C:3]1[C:4](N[C@@H]2C3C(=CC=CC=3)C[C@@H]2O)=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2].[CH3:22][O:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[CH:30]([NH2:34])[CH2:29][CH2:28][CH2:27]2>>[CH2:1]([C:3]1[C:4]([NH:34][CH:30]2[C:31]3[C:26](=[CH:25][C:24]([O:23][CH3:22])=[CH:33][CH:32]=3)[CH2:27][CH2:28][CH2:29]2)=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 382506-Methoxy-1,2,3,4-tetrahydro-1-naphthalenylamineHCID 58583341(1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

생성물 1

HCID 221472773,6-diethyl-N-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

실험 절차

Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine and making non-critical variations provided the title compound as a oil: HRMS (FAB) calcd for C19H25N3O+H 312.2076, found 312.2075; Anal. Calcd for C19H25N3O: C, 73.28; H, 8.09; N, 13.49. Found: C, 73.38; H, 8.11; N, 13.32.

출처 및 근거

ORD 기록
ord-c0960bb1af6348eab01e89eee7f762c9
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041672B2

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