(1R,2R)-1-Amino-1,2,3,4-tetrahydronaphthalen-2-ol → HCID 58583495, compound

HRID 1824101Notes

Reaction equation

HRID 1824101 reaction equation
[CH2:1]([C:3]1[C:4]([NH:11][C@@H:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][C@@H:13]2[OH:21])=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2].N[C@@H:23]1C2C(=CC=CC=2)CC[C@H]1O>>[CH2:1]([C:3]1[C:4]([NH:11][C@@H:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:23][CH2:14][C@H:13]2[OH:21])=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 13125680(1R,2R)-1-Amino-1,2,3,4-tetrahydronaphthalen-2-olHCID 58583341(1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

Product 1

HCID 58583495HCID 58583495, compound

Procedure

Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting (trans)-1-amino-1,2,3,4-tetrahydronaphthalen-2-ol and making non-critical variations provided the title compound as a oil: 1H NMR (CDCl3) δ 1.27–1.34, 2.01, 2.24, 2.64, 2.84, 2.93, 4.03, 4.76, 5.06, 5.17, 7.19–7.21, 7.25–7.27, 7.34–7.37, 7.66;

Sources & evidence

ORD record
ord-83800f13f2784b28874f36cba755dc76
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

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