HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydro-2-naphthalenol → HCID 69663884, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydro-2-naphthalenol | HCID 10747 | — |
| Reactant | (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol | HCID 58583246 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 69663884 | HCID 69663884 | — |
Reaction Steps
Following the procedure for the preparation of (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol but substituting cis-(5-bromo-3,6-diethylpyrazin-2-yl)amino]-1,2,3,4-tetrahydronaphthalen-2-ol, ethylene glycol dimethyl ether and tetrakis(triphenylphosphine) palladium and making non-critical variations provided the title compound as a oil: 1H NMR (CDCl3) δ 1.18–1.31, 2.09, 2.54, 2.64, 2.95, 2.99, 4.33, 4.69, 5.43, 7.22–7.35, 7.51; HRMS (FAB) calcd for C24H25Cl2N3O+H 442.1453, found 442.1454.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07041672B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-d8e5e2d21bdc4c8eace2dbd035803f2a |
| Source note | uspto-grants-2006_05 |