5-Methyl-4,5,6,7-tetrahydro-1-benzothiophen-4-amine → 3,6-diethyl-N-(5-methyl-4,5,6,7-tetrahydro-1-benzothien-4-yl)pyrazin-2-amine

HRID 1824111Notes

Reaction equation

HRID 1824111 reaction equation
[CH2:1]([C:3]1[C:4]([NH:11][C@@H:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][C@@H:13]2O)=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2].CC1C(N)C2C=C[S:30]C=2CC1>>[CH2:1]([C:3]1[C:4]([NH:11][CH:12]2[C:20]3[CH:19]=[CH:18][S:30][C:15]=3[CH2:16][CH2:17][CH:13]2[CH3:14])=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 203489295-Methyl-4,5,6,7-tetrahydro-1-benzothiophen-4-amineHCID 58583341(1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

Product 1

HCID 221472573,6-diethyl-N-(5-methyl-4,5,6,7-tetrahydro-1-benzothien-4-yl)pyrazin-2-amine

Procedure

Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 5-methyl-4,5,6,7-tetrahydro-1-benzothien-4-ylamine and making non-critical variations provided the title compound as a oil: 1H NMR (400 MHz, CDCl3) δ) 7.66, 7.07, 6.91, 6.83, 5.62, 5.15, 4.46, 4.35, 3.09, 2.65–2.55, 2.28, 2.06–1.97, 1.80, 1.29, 1.11, 1.01; (MS/CI) calcd for C17H23N3S+H 301.6, found 301.9.

Sources & evidence

ORD record
ord-3f72c6ae33884679995094e1f9297084
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

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