Isopropyl iodide → HCID 10127396, compound

Participants

Reaction Steps

Following the procedure for the preparation of 5-(2,4-dichlorophenyl)-N-[(1R,2S)-2-ethoxy-2,3-dihydro-1H-inden-1-yl]-3,6-diethylpyrazin-2-amine but substituting (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-dimethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol and 2-iodopropane, and making non-critical variations provided the title compound as a oil: 1H NMR (300 MHz, CDCl3) δ) 7.50–7.46, 7.34–7.26, 5.76, 5.43, 4.47, 3.72, 3.14–3.11, 2.41, 2.26, 1.20, 1.12; HRMS (FAB) calcd for C24H25Cl2N3O+H 442.1453, found 442.1441. Anal. Calcd for C24H25Cl2N3O: C, 65.16; H, 5.70; N, 9.50. Found: C, 65.33; H, 5.83; N, 9.34.

Provenance & Evidence