反应详情

Following the procedure for the preparation of (1R,2S)-1-{[5-(2,4-dichlorophenyl)-3,6-diethylpyrazin-2-yl]amino}-2,3-dihydro-1H-inden-2-ol but substituting N-(5-bromo-3,6-diethylpyrazin-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-5-amine, ethylene glycol dimethyl ether and tetrakis(triphenylphosphine) palladium and making non-critical variations provided the title compound as a oil: 1H NMR (400 MHz, CDCl3) δ) 8.50, 7.73, 7.51, 7.36–7.28, 7.17, 5.88, 4.67, 3.26–3.08, 2.86, 2.70, 2.51, 2.05–1.96, 1.29, 1.12; HRMS (FAB) calcd for C22H22Cl2N4+H 413.1299, found 413.1286.