methyl N-{2-[(tert-butoxycarbonyl)amino]butanoyl}alaninate → methyl N-(2-aminobutanoyl)alaninate hydrochloride

HRID 1824237Notes

Reaction equation

HRID 1824237 reaction equation
[ClH:1].COC(=O)C(NC(=O)[C@H](C)N)C1CC1.C(OC([NH:23][CH:24]([CH2:34][CH3:35])[C:25]([NH:27][C@H:28]([C:30]([O:32][CH3:33])=[O:31])[CH3:29])=[O:26])=O)(C)(C)C>>[ClH:1].[NH2:23][CH:24]([CH2:34][CH3:35])[C:25]([NH:27][C@H:28]([C:30]([O:32][CH3:33])=[O:31])[CH3:29])=[O:26]

Participants

3

Reactant 2

HCID 86588879methyl N-{2-[(tert-butoxycarbonyl)amino]butanoyl}alaninateHCID 86588880methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride

Product 1

HCID 86588882methyl N-(2-aminobutanoyl)alaninate hydrochloride

Procedure

Following the procedure for the preparation of methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride but substituting methyl N-{2-[(tert-butoxycarbonyl)amino]butanoyl}alaninate and making non-critical variations provided the title compound asia solid: 1H NMR (DMSO-d6) δ 0.86–0.92, 1.39–1.41, 1.62–1.82, 3.64, 3.92, 4.18–4.23, 8.36, 8.92.

Sources & evidence

ORD record
ord-7508a023a2964348aff876be1ea4456b
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

Loading…