HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride → 3-Cyclopropyl-6-methylpiperazine-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride | HCID 86588880 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Cyclopropyl-6-methylpiperazine-2,5-dione | HCID 22147368 | 128.7% |
Reaction Steps
A solution of methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride (230 mg, 0.97 mmol) in 7 N NH3 in MeOH (6 mL) was heated at reflux for 5 hr. Cool to rt and concentrate. The resulting material was dried at rt/0.5 mm Hg to provide 0.21 g of 3-cyclopropyl-6-methylpiperazine-2,5-dione as a solid: 1H NMR (CDCl3) δ 0.26–0.51, 1.06–1.37, 3.16–3.25, 3.50, 3.80, 4.00, 8.13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07041672B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-387ba09e09404805bb7e9bb6ba00a64b |
| Source note | uspto-grants-2006_05 |