3-Cyclopropyl-6-methylpiperazine-2,5-dione → 3-Ethyl-6-methylpiperazine-2,5-dione

HRID 1824240Notes

Reaction equation

HRID 1824240 reaction equation
[CH:1]1([CH:4]2[NH:9][C:8](=[O:10])[CH:7]([CH3:11])[NH:6][C:5]2=[O:12])C[CH2:2]1.Cl.NC(CC)C(N[C@H](C(OC)=O)C)=O>>[CH2:1]([CH:4]1[NH:9][C:8](=[O:10])[CH:7]([CH3:11])[NH:6][C:5]1=[O:12])[CH3:2]

Participants

3

Reactant 2

HCID 221473683-Cyclopropyl-6-methylpiperazine-2,5-dioneHCID 86588882methyl N-(2-aminobutanoyl)alaninate hydrochloride

Product 1

HCID 221474093-Ethyl-6-methylpiperazine-2,5-dione

Procedure

Following the procedure for the preparation of 3-cyclopropyl-6-methylpiperazine-2,5-dione but substituting methyl N-(2-aminobutanoyl)alaninate hydrochloride and making non-critical variations provided the title compound as a solid: 1H NMR (DMSO-d6) δ 60.81–0.86, 1.25–1.27, 1.64–1.76, 3.73–3.91, 7.37, 8.07–8.15.

Sources & evidence

ORD record
ord-ffcc1d2439a74938a7bd63d403299d65
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

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