3-Chloro-2,5-diethylpyrazine → 3-Chloro-2,5-dicyclopropylpyrazine

HRID 1824241Notes

Reaction equation

HRID 1824241 reaction equation
[Cl:1]C1C(CC)=NC=C(CC)N=1.[CH:12]1([CH:15]2[NH:20][C:19](=O)[CH:18]([CH:22]3[CH2:24][CH2:23]3)[NH:17][C:16]2=O)[CH2:14][CH2:13]1>>[Cl:1][C:19]1[C:18]([CH:22]2[CH2:24][CH2:23]2)=[N:17][CH:16]=[C:15]([CH:12]2[CH2:14][CH2:13]2)[N:20]=1

Participants

3

Reactant 2

HCID 2373953-Chloro-2,5-diethylpyrazineHCID 221474273,6-Dicyclopropylpiperazine-2,5-dione

Product 1

HCID 221475303-Chloro-2,5-dicyclopropylpyrazine

Procedure

Following the procedure for the preparation of 3-chloro-2,5-diethylpyrazine but substituting 3,6-dicyclopropylpiperazine-2,5-dione and making non-critical variations provided the title compound as an oil: 1H NMR (CDCl3) δ 0.99–1.13, 1.94–2.03, 2.38–2.47; MS (ESI+) for C10H11N2 m/z 195 (M+H)+.

Sources & evidence

ORD record
ord-b93fba5255ea482a8f6f9e5268852b35
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

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