HCID 22147494, compound → HCID 58583262, compound

HRID 1824247Notes

Reaction equation

HRID 1824247 reaction equation
[CH2:1]([C:3]1[C:4]([NH:11][C@@H:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][C@@H:13]2[OH:21])=[N:5][C:6]([CH2:9][CH3:10])=[CH:7][N:8]=1)[CH3:2].Cl[C:23]1C(CC)=NC=C(C2CC2)N=1>>[CH:9]1([C:6]2[N:5]=[C:4]([NH:11][C@@H:12]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH2:14][C@@H:13]3[OH:21])[C:3]([CH2:1][CH3:2])=[N:8][CH:7]=2)[CH2:23][CH2:10]1

Participants

3

Reactant 2

HCID 22147494HCID 22147494, compoundHCID 58583341(1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

Product 1

HCID 58583262HCID 58583262, compound

Procedure

Following the procedure for the preparation of (1R,2S)-1-[(3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 3-chloro-5-cyclopropyl-2-ethylpyrazine and making non-critical variations provided the title compound as a solid: 1H NMR (CDCl3) δ 0.92–0.95, 1.31–1.35, 1.93, 2.59–2.70, 3.03–3.10, 3.22–3.30, 4.74, 4.91, 5.49–5.52, 7.28–7.32, 7.82; MS (ESI+) for C18H21N3O m/z 296 (M+H)+.

Sources & evidence

ORD record
ord-b64c58baa7764f048968dde7391518a9
Source dataset
uspto-grants-2006_05
Patent number
US07041672B2

Reaction notes

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