Bromine → HCID 22148769, compound

HRID 1824348Notes

Reaction equation

HRID 1824348 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:12]=[C:13]([Cl:17])[CH:14]=[N:15][CH:16]=1)[NH2:6])#[N:2].[Br:18]Br>C(O)(=O)C>[NH2:6][C:5]1[CH:7]=[CH:8][C:9]([O:10][C:11]2[CH:12]=[C:13]([Cl:17])[CH:14]=[N:15][CH:16]=2)=[C:3]([C:1]#[N:2])[C:4]=1[Br:18]

Participants

4

Reactant 2

HCID 24408BromineHCID 12112539HCID 12112539, compound

Product 1

HCID 22148769HCID 22148769, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3-Cyano-4-(3-chloro-5-pyridyloxy)aniline (see Example 2) was combined with bromine in acetic acid in a manner similar to that described in Example 40 to produce 5-(4-amino-2-cyano-3-bromophenoxy)-3-chloropyridine (37%) after chromatography.

Sources & evidence

ORD record
ord-4e2d12752ba249a2a3b3c2af650a6278
Source dataset
uspto-grants-2006_05
Patent number
US07041691B1

Reaction notes

Loading…