HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Chloro-N-[3-chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-4-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride | HCID 2736675 | — |
| Reactant | 3-Chloro-4-(napthalen-2-ylsulfanyl)-phenylamine | HCID 9861938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-N-[3-chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-4-trifluoromethyl-benzenesulfonamide | HCID 22148787 | 90% |
Reaction Steps
The title compound was prepared using the method of example 94, starting with 3-chloro-4-(naphthalen-2-ylsulfanyl)-phenylamine (150 mg, 0.53 mmol), pyridine (Aldrich, 0.21 mL, 2.63 mmol) and 2-chloro-4-trifluoromethylbenzenesulfonyl chloride (Maybridge, 162 mg, 0.58 mmol) in THF. 250 mg (90%) of title compound (95) was obtained as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07041691B1 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-8d383872224f4530be489037917ab4f8 |
| Source note | uspto-grants-2006_05 |