Pyridine → N-[3-Chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-4-iodo-benzenesulfonamide

HRID 1824361노트

반응식

HRID 1824361 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[CH:6][C:7]=1[S:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1.N1C=CC=CC=1.[I:26][C:27]1[CH:32]=[CH:31][C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][CH:28]=1>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:19][S:33]([C:30]2[CH:31]=[CH:32][C:27]([I:26])=[CH:28][CH:29]=2)(=[O:35])=[O:34])[CH:5]=[CH:6][C:7]=1[S:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 73994-Iodobenzenesulfonyl chlorideHCID 98619383-Chloro-4-(napthalen-2-ylsulfanyl)-phenylamine

생성물 1

HCID 22148807N-[3-Chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-4-iodo-benzenesulfonamide수율 53%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound was prepared using the method of example 94, starting with 3-chloro-4-(naphthalen-2-ylsulfanyl)-phenylamine (92)(150 mg, 0.53 mmol), pyridine (Aldrich, 0.21 mL, 2.63 mmol) and 4-iodobenzenesulfonyl chloride (Acros, 175 mg, 0.58 mmol) in THF. 153 mg (53%) of 100 was obtained as a pale yellow solid.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-ec90eb82f2c9443892fb0e38ec5720e0
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041691B1

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